City of a Thousand Towers
Ioqua is a liquid, sometimes a powder, that is essentially congealed magically energy. It is a product of arcane minerals in the mountains of Ultima Borea and magic forces unleashed by the Witch King and his minions.
Ioqua can be used to replace most material components when enhancing magical items. Just dipping a magic item in Ioqua will either destroy it by adding its essence and increasing the Ioqua or add a random enchantment to it (and consuming the Ioqua) or destroying both item and Ioqua in a burst of chaotic energy similar to the effect of a rod of wonder.
Marselene thinks that your god-touched (aka mythic) items may be immune to Ioqua’s effects but she is uncertain.